You are not currently logged in. Please create an account or log in to view the full course.
6. Mutation, Damage and Repair
About this Lecture
In the sixth and final mini-lecture, we take a brief look at some of the ways that DNA can be mutated and damaged, such as by substitution, deletion and insertion. In this mini-lecture we learn what can happen to proteins when this happens, either when it is in a coding or non-coding section. We also acknowledge the redundancy of DNA, meaning its ability to still code for the same protein even if mutations occur.
In this lecture, Professor Richard Bowater (University of East Anglia) talks about DNA, its structure, its replication and how it can code for proteins. To do so, we: (i) discuss the microscopic structure of DNA, looking at what each monomer (nucleotide) is made of; before (ii) understanding the history of its discovery and the macroscopic structure; following onto (iii) DNA polymerase and its role in DNA synthesis; which then goes on to (iv) the coding and non-coding sections of DNA and how four nucleotides code for 20 amino acids; before (v) diving into the step-by-step process of how new nucleotides are added to DNA; and then finally (vi) understanding how DNA can be mutated and damaged, and some of the implications this can have on the proteins it codes for.
Having trained as a biochemist, Professor Richard Bowater's research interests broadened out to encompass methodologies that involve biophysical chemistry, microbiology, molecular biology and bioinformatics. His research focuses on macromolecular interactions of bacterial DNA repair proteins, particularly DNA and RNA ligases, with experiments performed in vitro or in bacterial model organisms. His areas of expertise include the relationship of genetic instabilities to human diseases; trinucleotide (triplet) repeat expansions and human neurodegenerative disorders; DNA repair processes; and protein-protein and protein-DNA interactions.
Cite this Lecture
Bowater, R. (2022, September 28). DNA Structure and Replication - Mutation, Damage and Repair [Video]. MASSOLIT. https://www.massolit.io/courses/dna-structure-and-replication/mutation-damage-and-repair
Bowater, R. "DNA Structure and Replication – Mutation, Damage and Repair." MASSOLIT, uploaded by MASSOLIT, 28 Sep 2022, https://www.massolit.io/courses/dna-structure-and-replication/mutation-damage-and-repair